The headline speaker is vice-presidential nominee Paul Ryan, who will have his big moment in the Klieg lights when addressing delegates and the nation post-10 p.m. EST. Immediately preceding him are former Secretary of State Condoleezza Rice and former Minnesota Gov. Tim Pawlenty.
There is also a featured Latino speaker every night to show that the Republicans want to pick up polling with Hispanic voters. On Wednesday, much of the country will meet Puerto Rican Governor Luis Fortuño for the first time.
Jeb Bush, the man who might have run for president this year, speaks before the delegates earlier in the evening. He's billed sixth in the line-up behind Ohio Sen. Rob Portman.
Getting a big platform is Florida Attorney General Pam Bondi, who undoubtedly will speak about the Sunshine State's opposition to President Obama's health care plan. Bondi inherited the lawsuit initiated by her predecessor, Bill McCollum, who claimed the individual mandate provision of the bill was unconstitutional — a suit that 25 other states later joined. The lawsuit made its way to the U.S. Supreme Court, which stunningly upheld its constitutionality in a decision announced in late June.
The Florida AG will remind delegates that the only way to repeal what critics dub "ObamaCare" is to elect Mitt Romney president.
Bondi is higher in the line-up than the GOP's standard bearer from four short years ago, Arizona Sen. John McCain. South Dakota Sen. John Thune and Mr. Happy, Senate Minority Leader Mitch McConnell of Kentucky, round off Wednesday's list of notable speakers.